This update contains:

• AGORA 1.03 reconstructions available
• 396 new pictures of metabolites
• Possibility to download all the RXN files for all the reactions
• Design

This update contains:

• Map metabolites and reactions to the organelle maps
• External links presentation
• Addition of smiles, inchi string and inchi key
• Addition of documentation for the API

Gene external IDs addition details:

Resource	Count
Ensembl transcript id (ENST)	3510

Metabolite external IDs addition details:

Resource Diseases	Count
CHO Models	2029

Reaction external IDs addition details:

Resource Diseases	Count
CHO Models	5185

This update contains:

Reaction external IDs addition details:

Resource	Count
Rhea	895

Disease external IDs addition details:

Resource Diseases	Count
1000 genomes	255
ClinGene Dosage	255
ClinicalTrials.gov	130
ClinVar	255
EuroGenTest	228
GARD	184
Genetic Alliance	191
Gene Reviews	88
Geno2MP	248
GWAS Catalog	187
GWAS Central	253
LOVD	254
MalaCards	206
OMIM	247
OMIM Clinical Symptoms	230
OrphaNet	223
Wikipedia	201

This update contains:

Gene external IDs addition details:

Resource	Count
Wikipedia	2081
GeneCard	1708
UniProt	493

Metabolite external IDs addition details:

Resource	Count
Wikipedia	84
DrugBank	180
KEGG ID	4
CHEBI ID	25
ChemSpider	24
CAS Number	37
PubChem id	9
KNApSAcK	204
BIGG identifier	396
ChEMBL	312
ECHA ( European chemicals agency)	452
IUPHAR Ligand id	173
FDA UNII (unique ingredient identifier)	316

Diseases external IDs addition details:

Resource Diseases	Count
GTR (Genetic testing registry)	241
CellLines (Coriell Institute)	110
MGI (Mouse Genome Informatics)	148

Metabolite external IDs update details:

Resource	Count
DrugBank	23
BIGG identifier	814

This update contains:

• Bug and usability fixes
• Update of fermentation products and carbon sources for the Gut microbiota resource
• Update of spy plots for the Gut microbiota resource
• Update of ReconMaps to include Google License terms
• Addition of external IDs for Microbe and Gene entities - detailed below.

Microbe external IDs update details:

Resource	Count
Microbe wiki	221
UniProt	815
Ensembl Bacteria	679
ENA	679
JGI Gold	815

Gene external IDs update details:

Resource	Count
DiseaseMeth	3548
GWAS Catalog	2717
GenoMP	3578
LOVD	3624
GHR	1512
ClinGen	3653
GWAS Central	3591
DECIPHER	3671